Marlboro County, South Carolina was established on March 2, 1785 and was originally called Marlboro District. It was named for John Churchill, first Duke of Marlborough, whose Blenheim Palace in Oxfordshire, England, was a gift to him from Queen Anne. Marlboro District was carved from Cheraw District. Later Marlboro, Chesterfield, and Darlington Districts became Counties.

When Marlboro County, South Carolina was created, legislation required that each district select a site and erect a courthouse and jail. The site chosen for Marlboro County's first courthouse was on the banks of the Great Pee Dee River near Gardner's Bluff. A few years later, it was moved a short distance inland and near the north bank of Crooked Creek where it crossed the old River Road. The county's first town named either Carlisle or Winnfieldville was developed. Its presence is no longer noticeable except for a granite marker denoting the location of the first courthouse as being at that location.